The Threading Approach to Tertiary Structure Prediction


The threading and sequence-structure alignment approachs are based on the observation that many protein structures in the PDB are very similar. For example, there are many 4-helical bundles, TIM barrels, globins, etc. in the set of solved structures. As a result of this, many scientists have conjectured there are only a limited number of “unique” protein… (More)

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