The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).

@article{Singer2016TheTI,
  title={The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).},
  author={Mervyn Singer and Clifford S. Deutschman and Christopher W. Seymour and Manu Shankar-Hari and Djillali Annane and Michael Bauer and Rinaldo Bellomo and Gordon R. Bernard and Jean Daniel Chiche and Craig M. Coopersmith and Richard S Hotchkiss and Mitchell M. Levy and John C. Marshall and Greg S. Martin and Steven M. Opal and Gordon David Rubenfeld and Tom van der Poll and Jean Louis Vincent and Derek C. Angus},
  journal={JAMA},
  year={2016},
  volume={315 8},
  pages={
          801-10
        }
}
IMPORTANCE Definitions of sepsis and septic shock were last revised in 2001. [] Key MethodPROCESS A task force (n = 19) with expertise in sepsis pathobiology, clinical trials, and epidemiology was convened by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine.

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The Sequential (Sepsis-related) Organ Failure Assessment (SOFA) criteria and “quick” (q)SOFA criteria should be used to identify sepsis, in place of the currently used systemic inflammatory response syndrome (SIRS) criteria, which were the basis for the previous definition of sepsi.

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A consensus process using results from a systematic review, surveys, and cohort studies found that adult patients with septic shock can be identified using the clinical criteria of hypotension requiring vasopressor therapy to maintain mean BP 65 mm Hg or greater and having a serum lactate level greater than 2 mmol/L after adequate fluid resuscitation.

The New Sepsis Definitions: Implications for Critical Care Practitioners.

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This article reviews highlights of the new sepsis definitions, including implications for practicing critical care clinicians, and uses clinical criteria for sepsi surveillance and identification based on prior consensus definitions.

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Evaluation and management of suspected sepsis and septic shock in adults

In this topic review, the management of sepsis and septic shock is discussed and definitions, diagnosis, pathophysiology, and investigational therapies for sepsi, as well as management ofsepsis in the asplenic patient are reviewed separately.

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...

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