The Thermoplasma acidophilum LplA-LplB complex defines a new class of bipartite lipoate-protein ligases.

@article{Christensen2009TheTA,
  title={The Thermoplasma acidophilum LplA-LplB complex defines a new class of bipartite lipoate-protein ligases.},
  author={Quin H. Christensen and John E. Cronan},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 32},
  pages={21317-26}
}
Lipoic acid is a covalently bound cofactor found throughout the domains of life that is required for aerobic metabolism of 2-oxoacids and for C(1) metabolism. Utilization of exogenous lipoate is catalyzed by a ligation reaction that proceeds via a lipoyl-adenylate intermediate to attach the cofactor to the epsilon-amino group of a conserved lysine residue of protein lipoyl domains. The lipoyl ligases of demonstrated function have a large N-terminal catalytic domain and a small C-terminal… CONTINUE READING

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