The Thermogenic Effect of Leptin Is Dependent on a Distinct Population of Prolactin-Releasing Peptide Neurons in the Dorsomedial Hypothalamus

@inproceedings{Dodd2014TheTE,
  title={The Thermogenic Effect of Leptin Is Dependent on a Distinct Population of Prolactin-Releasing Peptide Neurons in the Dorsomedial Hypothalamus},
  author={Garron T Dodd and Amy A. Worth and Nicolas Nunn and Aaron K. Korpal and David A Bechtold and Margaret B. Allison and Martin G Myers and Michael A. Statnick and Simon M. Luckman},
  booktitle={Cell metabolism},
  year={2014}
}
Leptin is a critical regulator of metabolism, which acts on brain receptors (Lepr) to reduce energy intake and increase energy expenditure. Some of the cellular pathways mediating leptin's anorectic actions are identified, but those mediating the thermogenic effects have proven more difficult to decipher. We define a population of neurons in the dorsomedial hypothalamic nucleus (DMH) containing the RFamide PrRP, which is activated by leptin. Disruption of Lepr selectively in these cells blocks… CONTINUE READING
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