The Therapeutic Potential of κ-Opioids for Treatment of Pain and Addiction

@article{Chavkin2011TheTP,
  title={The Therapeutic Potential of κ-Opioids for Treatment of Pain and Addiction},
  author={Charles Chavkin},
  journal={Neuropsychopharmacology},
  year={2011},
  volume={36},
  pages={369-370}
}
pothalamic BDNF participates in homeostatic processes that preserve energy levels essential for survival. Recently, we demonstrated an intimate involvement of BDNF in the regulation of hedonic feeding via the positive modulation of the mesolimbic dopamine pathway (Cordeira et al, 2010). This neural circuit mediates motivated and reward-seeking behaviors, including consumption of palatable food, and has well-established roles in drug addiction. Mice with selective deletion of Bdnf in the ventral… CONTINUE READING