The Therapeutic Implications of Plasticity of the Cancer Stem Cell Phenotype

@inproceedings{Leder2010TheTI,
  title={The Therapeutic Implications of Plasticity of the Cancer Stem Cell Phenotype},
  author={Kevin Leder and Eric C. Holland and Franziska Michor},
  booktitle={PloS one},
  year={2010}
}
The cancer stem cell hypothesis suggests that tumors contain a small population of cancer cells that have the ability to undergo symmetric self-renewing cell division. In tumors that follow this model, cancer stem cells produce various kinds of specified precursors that divide a limited number of times before terminally differentiating or undergoing apoptosis. As cells within the tumor mature, they become progressively more restricted in the cell types to which they can give rise. However, in… CONTINUE READING
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