The Therapeutic Effects of Tyrosine Hydroxylase Gene Transfected Hematopoetic Stem Cells in a Rat Model of Parkinson’s Disease

@article{Zhang2007TheTE,
  title={The Therapeutic Effects of Tyrosine Hydroxylase Gene Transfected Hematopoetic Stem Cells in a Rat Model of Parkinson’s Disease},
  author={Shizhong Zhang and Zhihao Zou and Xiaodan Jiang and Ruxiang Xu and Wangming Zhang and Yuan Zhou and Yiquan Ke},
  journal={Cellular and Molecular Neurobiology},
  year={2007},
  volume={28},
  pages={529-543}
}
To investigate the therapeutic effects of tyrosine hydroxylase (TH)-transfected neuronal stem cells derived from bone marrow stem cells (NdSCs-D-BMSCs) on Parkinson’s disease (PD) through different transplantation protocols, including microinjection into the cerebral ventricles (CV) and the striatum (ST). After identification by enzyme digestion, the constructed plasmid pEGFP-C2-TH was transfected into 8-day-cultured NdSCs-D-BMSCs by electroporation resulting in the coexpression of green… CONTINUE READING

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