The Th2 cytokine, interleukin-4, abrogates the cohesion of normal stratum corneum in mice: implications for pathogenesis of atopic dermatitis.

@article{Hatano2013TheTC,
  title={The Th2 cytokine, interleukin-4, abrogates the cohesion of normal stratum corneum in mice: implications for pathogenesis of atopic dermatitis.},
  author={Yutaka Hatano and Yasuko Adachi and Peter M. Elias and Debra A. Crumrine and Takashi Sakai and Rieko Kurahashi and Kazumoto Katagiri and Sakuhei Fujiwara},
  journal={Experimental dermatology},
  year={2013},
  volume={22 1},
  pages={
          30-5
        }
}
There is mounting evidence that Th2 cytokines adversely affect skin barrier functions and contribute to the pathogenesis of atopic dermatitis (AD). AD is also characterized by abnormal cohesion in the stratum corneum (SC). However, the contribution of Th2 cytokines to this abnormality remains unknown. This study examined the effects of IL-4, a prototypic Th2 cytokine, on the cohesion of the SC. Structural and physiological assessments revealed that repeated intradermal injections of IL-4… CONTINUE READING

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