The Th17–ELR+ CXC chemokine pathway is essential for the development of central nervous system autoimmune disease

@article{Carlson2008TheTC,
  title={The Th17–ELR+ CXC chemokine pathway is essential for the development of central nervous system autoimmune disease},
  author={Thaddeus J. Carlson and Mark A. Kroenke and P Syamasundar Rao and Thomas E Lane and Benjamin M Segal},
  journal={The Journal of Experimental Medicine},
  year={2008},
  volume={205},
  pages={811 - 823}
}
The ELR(+) CXC chemokines CXCL1 and CXCL2 are up-regulated in the central nervous system (CNS) during multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). However, their functional significance and the pathways regulating their expression are largely unknown. We show that transfer of encephalitogenic CD4(+) Th17 cells is sufficient to induce CXCL1 and CXCL2 transcription in the spinal cords of naive, syngeneic recipients. Blockade or genetic silencing… CONTINUE READING
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