The Th1-Th2 hypothesis of HIV infection: new insights.

  title={The Th1-Th2 hypothesis of HIV infection: new insights.},
  author={Mario Clerici and Gene M. Shearer},
  journal={Immunology today},
  volume={15 12},
In their earlier, much quoted, viewpoint article, Mario Clerici and Gene Shearer examined the role of T helper 1 (Th1)- and Th2-type responses in immune dysregulation associated with human immunodeficiency virus (HIV) infection. In this article, they consider the complications of a Th1-Th2 model raised by the nomenclature, discuss the issue of cytokine production by non-T cells, and compare data obtained from T-cell clones with heterogeneous populations of leukocytes from patients. They define… CONTINUE READING
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