The Th1/Th2 paradigm and the allograft response.

  title={The Th1/Th2 paradigm and the allograft response.},
  author={Terry B. Strom and Prabir Roy-Chaudhury and R C Manfro and Xin Xiao Zheng and Peter W. Nickerson and Katrina Wood and Andrew C. Bushell},
  journal={Current opinion in immunology},
  volume={8 5},
Although Th1- and Th2-type cytokine profiles have been associated with rejection and tolerance respectively, this paradigm may not be completely accurate. Instead, recent studies suggest that there could be a hierarchy of T-cell growth factors with regard to their ability to block tolerance and induce rejection (rather than a polarized Th1/Th2 demarcation). 

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