The Th1/Th2 paradigm: still important in pregnancy?

  title={The Th1/Th2 paradigm: still important in pregnancy?},
  author={G{\'e}rard Chaouat},
  journal={Seminars in Immunopathology},
The enunciation of the T helper 1/T helper 2 (Th1/Th2) paradigm in pregnancy has represented a major step forward in our understanding of physiological and pathologic materno–foetal relationship. However, recent developments in studies of the implantation process and in the emergence of the uterine vascular bed and its control by natural killer cells and cytokines suggest that one must go beyond this hitherto useful scheme. In this review, we replace the emergence of the paradigm in its… CONTINUE READING
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