The Tg.AC (v-Ha-ras) transgenic mouse: nature of the model.

  title={The Tg.AC (v-Ha-ras) transgenic mouse: nature of the model.},
  author={Raymond W. Tennant and Stefan Stasiewicz and William C. Eastin and John H. Mennear and J. W. Spalding},
  journal={Toxicologic pathology},
  volume={29 Suppl},
The Tg.AC (v-Ha-ras) transgenic mouse model provides a reporter phenotype of skin papillomas in response to either genotoxic or nongenotoxic carcinogens. In common with the conventional bioassay, the Tg.AC model responds to known human carcinogens and does not respond to noncarcinogens. It also does not respond to most chemicals that are positive in conventional bioassays principally at sites of high spontaneous tumor incidence. The mechanism of response of the Tg.AC model is related to the… CONTINUE READING

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