The Terebridae and teretoxins: Combining phylogeny and anatomy for concerted discovery of bioactive compounds

@inproceedings{Puillandre2010TheTA,
  title={The Terebridae and teretoxins: Combining phylogeny and anatomy for concerted discovery of bioactive compounds},
  author={Nicolas Puillandre and M. E. Gwynne Holford},
  booktitle={BMC chemical biology},
  year={2010}
}
The Conoidea superfamily, comprised of cone snails, terebrids, and turrids, is an exceptionally promising group for the discovery of natural peptide toxins. The potential of conoidean toxins has been realized with the distribution of the first Conus (cone snail) drug, Prialt (ziconotide), an analgesic used to alleviate chronic pain in HIV and cancer patients. Cone snail toxins (conotoxins) are highly variable, a consequence of a high mutation rate associated to duplication events and positive… CONTINUE READING
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