The Temporal Relationship Between Symptom Change and Treatment Discontinuation in a Pooled Analysis of 4 Schizophrenia Trials

@article{Kinon2008TheTR,
  title={The Temporal Relationship Between Symptom Change and Treatment Discontinuation in a Pooled Analysis of 4 Schizophrenia Trials},
  author={B. Kinon and H. Ascher-Svanum and D. Adams and L. Chen},
  journal={Journal of Clinical Psychopharmacology},
  year={2008},
  volume={28},
  pages={544-549}
}
  • B. Kinon, H. Ascher-Svanum, +1 author L. Chen
  • Published 2008
  • Medicine, Psychology
  • Journal of Clinical Psychopharmacology
  • Treatment discontinuation is common in antipsychotic trials for the treatment of schizophrenia and is often associated with symptom worsening. This study assessed the timing and the magnitude of symptom change associated with treatment discontinuation for any cause, and whether improvement in specific symptom domains was predictive of treatment persistence. This post hoc analysis used pooled data from 1627 patients with schizophrenia spectrum disorders who were enrolled in 4 randomized, double… CONTINUE READING

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