The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor.

@article{Barillari1999TheTP,
  title={The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor.},
  author={Giovanni Barillari and Cecilia Sgadari and Valeria Fiorelli and Felipe Samaniego and Sandra Colombini and Vittorio Manzari and Andrea Modesti and Bala C. Nair and Aurelio Cafaro and Michael St{\"u}rzl and Barbara Ensoli},
  journal={Blood},
  year={1999},
  volume={94 2},
  pages={663-72}
}
The Tat protein of human immunodeficiency virus type-1 (HIV-1) has been shown to be released during acute infection of T cells by HIV-1 and to promote angiogenesis and Kaposi's sarcoma (KS) development in infected individuals. In this study, we investigated the molecular mechanisms responsible for the angiogenic effects of Tat. The results shown herein… CONTINUE READING