The Targeted Delivery of Multicomponent Cargos to Cancer Cells via Nanoporous Particle-Supported Lipid Bilayers

@inproceedings{Ashley2011TheTD,
  title={The Targeted Delivery of Multicomponent Cargos to Cancer Cells via Nanoporous Particle-Supported Lipid Bilayers},
  author={Carlee E. Ashley and Eric C. Carnes and Genevieve K. Phillips and David Padilla and Paul N. Durfee and Page A. Brown and Tracey N. Hanna and Juewen Liu and Brandy Phillips and Mark B. Carter and Nick J. Carroll and Xingmao Jiang and Darren R. Dunphy and Cheryl L. Willman and Dimiter N. Petsev and Deborah G. Evans and Atul N Parikh and Bryce Chackerian and Walker Wharton and David S. Peabody and C Jeffrey Brinker},
  booktitle={Nature materials},
  year={2011}
}
Encapsulation of drugs within nanocarriers that selectively target malignant cells promises to mitigate side effects of conventional chemotherapy and to enable delivery of the unique drug combinations needed for personalized medicine. To realize this potential, however, targeted nanocarriers must simultaneously overcome multiple challenges, including specificity, stability and a high capacity for disparate cargos. Here we report porous nanoparticle-supported lipid bilayers (protocells) that… CONTINUE READING
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