The Tall cell variant of papillary carcinoma of the thyroid: cytologic features and loss of heterozygosity of metastatic and/or recurrent neoplasms and primary neoplasms.

@article{Filie1999TheTC,
  title={The Tall cell variant of papillary carcinoma of the thyroid: cytologic features and loss of heterozygosity of metastatic and/or recurrent neoplasms and primary neoplasms.},
  author={Armando Carlos Filie and Alberto Chiesa and Bonita R. Bryant and Mar{\'i}a Jos{\'e} Beato Merino and Mark E. Sobel and Andrea Abati},
  journal={Cancer},
  year={1999},
  volume={87 4},
  pages={238-42}
}
BACKGROUND The Tall cell variant of papillary carcinoma of the thyroid (TCV) is characterized by the proliferation of oxyphilic, tall, columnar cells with a height-to-width ratio of at least 2:1. TCV exhibits more aggressive clinical behavior than conventional thyroid papillary carcinoma (CPC). Cytologic features suggestive of TCV have been described in fine-needle aspiration material from primary tumors. Similarly, loss of heterozygosity (LOH) for chromosome 1 (D1S243) and the p53 gene (TP53… CONTINUE READING

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