The TaClo concept: 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo), a new toxin for dopaminergic neurons.

@article{Bringmann1995TheTC,
  title={The TaClo concept: 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo), a new toxin for dopaminergic neurons.},
  author={Gerhard Bringmann and Ralf Dr. God and Doris Feineis and Wolfgang Wesemann and Peter Franz Riederer and Wolf Dieter Rausch and Heinz Reichmann and K. H. Sontag},
  journal={Journal of neural transmission. Supplementum},
  year={1995},
  volume={46},
  pages={
          235-44
        }
}
Due to its structural analogy to the neurotoxin MPTP, "TaClo" (1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline), a compound readily originating in vitro from tryptamine ("Ta") and chloral ("Clo"), is discussed as a potential natural inducer of parkinsonian-like symptoms. Its spontaneous formation in man has to be taken into account after application of the drug chloral hydrate or after exposure to the solvent trichloroethylene. This first representative of chloral-derived heterocycles could… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 15 CITATIONS

α-Synuclein in Parkinson’s disease: causal or bystander?

  • Journal of Neural Transmission
  • 2019
VIEW 2 EXCERPTS
CITES BACKGROUND

Trichloroethylene and Parkinson’s Disease: Risk Assessment

  • Molecular Neurobiology
  • 2017
VIEW 2 EXCERPTS
CITES BACKGROUND