The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis

@article{Fu2011TheTP,
  title={The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis},
  author={Junjiang Fu and Li Qin and Tao He and Jun Qin and Jun Euy Hong and Jiemin Wong and Lan Liao and Jianming Xu},
  journal={Cell Research},
  year={2011},
  volume={21},
  pages={275-289}
}
The epithelial-mesenchymal transition (EMT) converts epithelial tumor cells into invasive and metastatic cancer cells, leading to mortality in cancer patients. Although TWIST is a master regulator of EMT and metastasis for breast and other cancers, the mechanisms responsible for TWIST-mediated gene transcription remain unknown. In this study, purification and characterization of the TWIST protein complex revealed that TWIST interacts with several components of the Mi2/nucleosome remodeling and… CONTINUE READING