The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton.

@article{Haddad2002TheTT,
  title={The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton.},
  author={Luciana A. Haddad and Nicole V Smith and Mark J. Bowser and Yo Niida and Vanishree Murthy and Charo Gonzalez-Agosti and V Ramakrishnan Ramesh},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 46},
  pages={44180-6}
}
Tuberous sclerosis complex, an autosomal dominant disease caused by mutations in either TSC1 or TSC2, is characterized by the development of hamartomas in a variety of organs. The proteins encoded by TSC1 and TSC2, hamartin and tuberin, respectively, associate with each other forming a tight complex. Here we show that hamartin binds the neurofilament light chain and it is possible to recover the hamartin-tuberin complex over the neurofilament light chain rod domain spanning amino acids 93-156… CONTINUE READING