The TRPM7 channel is inactivated by PIP2 hydrolysis

@article{Runnels2002TheTC,
  title={The TRPM7 channel is inactivated by PIP2 hydrolysis},
  author={Loren W. Runnels and Lixia Yue and David E. Clapham},
  journal={Nature Cell Biology},
  year={2002},
  volume={4},
  pages={329-336}
}
TRPM7 (ChaK1, TRP-PLIK, LTRPC7) is a ubiquitous, calcium-permeant ion channel that is unique in being both an ion channel and a serine/threonine kinase. The kinase domain of TRPM7 directly associates with the C2 domain of phospholipase C (PLC). Here, we show that in native cardiac cells and heterologous expression systems, Gαq-linked receptors or tyrosine kinase receptors that activate PLC potently inhibit channel activity. Numerous experimental approaches demonstrated that phosphatidylinositol… 

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