The TRPM6 kinase domain determines the Mg·ATP sensitivity of TRPM7/M6 heteromeric ion channels.

@article{Zhang2014TheTK,
  title={The TRPM6 kinase domain determines the Mg·ATP sensitivity of TRPM7/M6 heteromeric ion channels.},
  author={Zheng Zhang and Haijie Yu and Junhao Huang and Malika Faouzi and Carsten Schmitz and Reinhold Penner and Andrea Fleig},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 8},
  pages={
          5217-27
        }
}
The transient receptor potential melastatin member 7 (TRPM7) and member 6 (TRPM6) are divalent cation channel kinases essential for magnesium (Mg(2+)) homeostasis in vertebrates. It remains unclear how TRPM6 affects divalent cation transport and whether this involves functional homomeric TRPM6 plasma membrane channels or heteromeric channel assemblies with TRPM7. We show that homomeric TRPM6 is highly sensitive to intracellular free Mg(2+) and therefore unlikely to be active at physiological… CONTINUE READING

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