The TRPC6 channel activator hyperforin induces the release of zinc and calcium from mitochondria.

@article{Tu2010TheTC,
  title={The TRPC6 channel activator hyperforin induces the release of zinc and calcium from mitochondria.},
  author={Peng Tu and Julien Gibon and Alexandre Bouron},
  journal={Journal of neurochemistry},
  year={2010},
  volume={112 1},
  pages={
          204-13
        }
}
Hyperforin, an extract of the medicinal plant hypericum perforatum (also named St John's wort), possesses antidepressant properties. Recent data showed that it elevates the intracellular concentration of Ca(2+) by activating diacylglycerol-sensitive C-class of transient receptor potential (TRPC6) channels without activating the other isoforms (TRPC1, TRPC3, TRPC4, TRPC5, and TRPC7). This study was undertaken to further characterize the cellular neuronal responses induced by hyperforin… CONTINUE READING

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