The TRPA1 channel in migraine mechanism and treatment.

  title={The TRPA1 channel in migraine mechanism and treatment.},
  author={Silvia Benemei and Camilla Fusi and Gabriela Trevisan and Pierangelo Geppetti},
  journal={British journal of pharmacology},
  volume={171 10},
Migraine remains an elusive and poorly understood disease. The uncertainty is reflected by the currently unsatisfactory acute and prophylactic treatments for this disease. Genetic and pharmacological information points to the involvement of some transient receptor potential (TRP) channels in pain mechanisms. In particular, the TRP vanilloid 1 (TRPV1) and TRP ankyrin 1 (TRPA1) channels seem to play a major role in different models of pain diseases. Recent findings have underscored the… CONTINUE READING
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