The TRP Superfamily of Cation Channels

@article{Montell2005TheTS,
  title={The TRP Superfamily of Cation Channels},
  author={Craig Montell},
  journal={Science's STKE},
  year={2005},
  volume={2005},
  pages={re3 - re3}
}
  • C. Montell
  • Published 2005
  • Biology, Medicine
  • Science's STKE
The transient receptor potential (TRP) protein superfamily consists of a diverse group of cation channels that bear structural similarities to Drosophila TRP. TRP channels play important roles in nonexcitable cells; however, an emerging theme is that many TRP-related proteins are expressed predominantly in the nervous system and function in sensory physiology. The TRP superfamily is divided into seven subfamilies, the first of which is composed of the "classical" TRPs" (TRPC subfamily). Some… Expand
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References

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Physiology, Phylogeny, and Functions of the TRP Superfamily of Cation Channels
TLDR
Investigations into the functions and modes of activation of TRP-related proteins have relevance for human health, because mutations in at least two members of the TRP superfamily are responsible for human diseases. Expand
Subunit composition of mammalian transient receptor potential channels in living cells
TLDR
This work investigates the combinatorial rules of TRPC assembly by pursuing four independent experimental approaches and shows that TRPC2 does not interact with any known TRPC protein andTRPC1 has the ability to form channel complexes together with TRPC4 and TRPC5. Expand
TRPC1 and TRPC5 Form a Novel Cation Channel in Mammalian Brain
TLDR
It is demonstrated here that TRPC1 and TRPC5 are subunits of a heteromeric neuronal channel, and proposed that many TRPC heteromers form diverse receptor-regulated nonselective cation channels in the mammalian brain. Expand
Formation of Novel TRPC Channels by Complex Subunit Interactions in Embryonic Brain*
TLDR
This complex assembly mechanism increases the diversity of TRPC channels in mammalian brain and may generate novel heteromers that have specific roles in the developing brain. Expand
TRPγ, a Drosophila TRP–Related Subunit, Forms a Regulated Cation Channel with TRPL
TLDR
It is demonstrated that TRPL-TRPgamma heteromultimers form a regulated phospholipase C- (PLC-) stimulated channel and contributes to the photoresponse of Drosophila. Expand
The Drosophila Light-Activated Conductance Is Composed of the Two Channels TRP and TRPL
TLDR
Drosophila phototransduction is a G protein-coupled, calcium-regulated signaling cascade that serves as a model system for the dissection of phospholipase C signaling in vivo and it is demonstrated that TRP and TRPL ion channels can serve partially overlapping functions. Expand
A unified nomenclature for the superfamily of TRP cation channels.
TLDR
The current effort to unify the TRP nomenclature focuses on three subfamilies that bear significant similarities to the founding member of this superfamily, Drosophila TRP, and which include highly related members in worms, flies, mice, and humans. Expand
Coassembly of TRP and TRPL Produces a Distinct Store-Operated Conductance
TLDR
It is reported that coexpression of TRP and TRPL leads to a store-operated, outwardly rectifying current distinct from that owing to either TRP or TRPL alone, and proposed that the light-activated current in photoreceptor cells is produced by a combination of TRp homo- and TRP-TRPL heteromultimers. Expand
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TLDR
It is demonstrated that TRPC channels are present in nerve terminals and provide the first direct evidence for selective assembly of channel subunits in vivo. Expand
trp, a Novel Mammalian Gene Family Essential for Agonist-Activated Capacitative Ca2+ Entry
TLDR
It is proposed that trp homologs are subunits of CCE channels, not unlike those of classical voltage-gated ion channels. Expand
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