The TRIM family protein KAP1 inhibits HIV-1 integration.

Abstract

The integration of viral cDNA into the host genome is a critical step in the life cycle of HIV-1. This step is catalyzed by integrase (IN), a viral enzyme that is positively regulated by acetylation via the cellular histone acetyl transferase (HAT) p300. To investigate the relevance of IN acetylation, we searched for cellular proteins that selectively bind… (More)
DOI: 10.1016/j.chom.2011.05.004

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