The TRIB3 R84 variant is associated with increased carotid intima-media thickness in vivo and with enhanced MAPK signalling in human endothelial cells.

@article{Formoso2011TheTR,
  title={The TRIB3 R84 variant is associated with increased carotid intima-media thickness in vivo and with enhanced MAPK signalling in human endothelial cells.},
  author={Gloria Formoso and Pamela Di Tomo and Francesco Andreozzi and Elena Succurro and Sara Di Silvestre and Sabrina Prudente and Francesco Perticone and Vincenzo Trischitta and Giorgio Sesti and Assunta Pandolfi and Agostino Consoli},
  journal={Cardiovascular research},
  year={2011},
  volume={89 1},
  pages={184-92}
}
AIMS TRIB3, a mammalian tribbles homologue, affects insulin signalling and action by inhibiting Akt phosphorylation. A TRIB3 Q84R gain-of-function polymorphism has been associated with insulin resistance both in vitro and in vivo and with several atherosclerotic phenotypes, including increased carotid intima-media thickness (IMT). We wanted to replicate this latter association and, if so, to get deeper insights about the molecular mechanisms underlying the role of the TRIB3 Q84R polymorphism in… CONTINUE READING