The TRH-metabolic histidyl-proline-diketopiperazine (DKP) inhibits prolactin secretion in male rhesus monkeys.

@article{Brabant1981TheTH,
  title={The TRH-metabolic histidyl-proline-diketopiperazine (DKP) inhibits prolactin secretion in male rhesus monkeys.},
  author={Georg Brabant and Elizabeth J Wickings and Eberhard Nieschlag},
  journal={Acta endocrinologica},
  year={1981},
  volume={98 2},
  pages={189-94}
}
Histidyl-proline-diketopiperazine (DKP) -- a stable degradation product of TRH -- has been shown to selectively inhibit prolactin secretion in vitro in rat pituitary tissue. In this study the effects of DKP on serum prolactin in intact and anaesthetized male rhesus monkeys and on TRH-stimulated prolactin levels have been investigated. In conscious monkeys 400 micrograms DKP significantly suppressed prolactin levels by 27%, and under ketamine anaesthesia, serum prolactin was suppressed in a dose… CONTINUE READING

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