The TREM2-DAP12 signaling pathway in Nasu–Hakola disease: a molecular genetics perspective

@article{Xing2015TheTS,
  title={The TREM2-DAP12 signaling pathway in Nasu–Hakola disease: a molecular genetics perspective},
  author={J. Xing and Amanda R Titus and M. Humphrey},
  journal={Research and reports in biochemistry},
  year={2015},
  volume={5},
  pages={89 - 100}
}
  • J. Xing, Amanda R Titus, M. Humphrey
  • Published 2015
  • Medicine
  • Research and reports in biochemistry
  • Nasu-Hakola disease or polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) is a rare recessively inherited disease that is associated with early dementia and bone cysts with fractures. [...] Key Result TREM2 and DAP12 form an immunoreceptor signaling complex that mediates myeloid cell, including microglia and osteoclasts, development, activation, and function. Functionally, TREM2-DAP12 mediates osteoclast multi-nucleation, migration, and resorption.Expand Abstract
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