The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.

@article{Krasemann2017TheTP,
  title={The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.},
  author={S. Krasemann and C. Madore and R. Cialic and Caroline Baufeld and Narghes Calcagno and Rachid El Fatimy and L. Beckers and E. O’Loughlin and Yang Xu and Zain Fanek and David J Greco and Scott t. Smith and G. Tweet and Zachary Humulock and T. Zrzavy and Patricia Conde-Sanroman and M. Gacias and Z. Weng and H. Chen and Emily C. Tjon and F. Mazaheri and Kristin Hartmann and A. Madi and J. Ulrich and M. Glatzel and Anna Worthmann and J. Heeren and B. Budnik and C. Lemere and T. Ikezu and F. Heppner and V. Litvak and D. Holtzman and H. Lassmann and H. Weiner and J. Ochando and C. Haass and O. Butovsky},
  journal={Immunity},
  year={2017},
  volume={47 3},
  pages={
          566-581.e9
        }
}
Microglia play a pivotal role in the maintenance of brain homeostasis but lose homeostatic function during neurodegenerative disorders. We identified a specific apolipoprotein E (APOE)-dependent molecular signature in microglia from models of amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and Alzheimer's disease (AD) and in microglia surrounding neuritic β-amyloid (Aβ)-plaques in the brains of people with AD. The APOE pathway mediated a switch from a homeostatic to a… Expand
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