The TRAIL to cancer therapy: Hindrances and potential solutions.

@article{Wong2019TheTT,
  title={The TRAIL to cancer therapy: Hindrances and potential solutions.},
  author={Sonia How Ming Wong and W. Kong and Chee-Mun Fang and H. Loh and L. Chuah and S. Abdullah and S. Ngai},
  journal={Critical reviews in oncology/hematology},
  year={2019},
  volume={143},
  pages={
          81-94
        }
}
Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. Resistance to apoptosis is a hallmark of virtually all malignancies. Despite being a cause of pathological conditions, apoptosis could be a promising target in cancer treatment. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), also known as Apo-2 ligand (Apo2L), is a member of TNF cytokine superfamily. It is a potent anti-cancer agent owing to its specific… Expand
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References

SHOWING 1-10 OF 195 REFERENCES
Onto better TRAILs for cancer treatment
Spatial dynamics of TRAIL death receptors in cancer cells.
Mechanisms of resistance to TRAIL-induced apoptosis in cancer
Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy.
...
1
2
3
4
5
...