The TRAIL of oncogenes to apoptosis.

@article{Oikonomou2013TheTO,
  title={The TRAIL of oncogenes to apoptosis.},
  author={Eftychia Oikonomou and Alexander Pintzas},
  journal={BioFactors},
  year={2013},
  volume={39 4},
  pages={
          343-54
        }
}
Despite the significant advances in clinical research, surgical resection, radiotherapy and chemotherapy are still used as the primary method for cancer treatment. As compared to conventional therapies that often induce systemic toxicity and eventually contribute to tumor resistance, the TNF-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent that selectively triggers apoptosis in various cancer cells by interacting with its proapoptotic receptors DR4 and KILLER/DR5, while… CONTINUE READING
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