The TRA-1 transcription factor binds TRA-2 to regulate sexual fates in Caenorhabditis elegans.

@article{Wang2001TheTT,
  title={The TRA-1 transcription factor binds TRA-2 to regulate sexual fates in Caenorhabditis elegans.},
  author={Shu Wang and Judith Kimble},
  journal={The EMBO journal},
  year={2001},
  volume={20 6},
  pages={
          1363-72
        }
}
The tra-1 and tra-2 sex-determining genes promote female fates in Caenorhabditis elegans. Classical genetic studies placed tra-1 as the terminal regulator of the pathway with tra-2 acting upstream as a regulator of regulators of tra-1. Here we report the surprising result that the TRA-1 transcription factor binds the intracellular domain of the TRA-2 membrane protein. This binding is dependent on the MX regulatory domain, a region of the TRA-2 intracellular domain shown previously to be… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 26 CITATIONS

Enigma variations: control of sexual fate in nematode germ cells

  • Genome Biology
  • 2006
VIEW 14 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The evolution of nematode sex determination: C. elegans as a reference point for comparative biology.

  • WormBook : the online review of C. elegans biology
  • 2005
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Sex-determination gene and pathway evolution in nematodes.

  • BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2003
VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Germ Cell Development in C. elegans

  • Advances in Experimental Medicine and Biology
  • 2013

Sex determination in the Caenorhabditis elegans germline.

  • Advances in experimental medicine and biology
  • 2013
VIEW 1 EXCERPT
CITES BACKGROUND

Using Caenorhabditis to explore the evolution of the germ line.

  • Advances in experimental medicine and biology
  • 2013
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 29 REFERENCES

MUTATIONS CAUSING TRANSFORMATION OF SEXUAL PHENOTYPE IN THE NEMATODE

CAENORHABDZTZS ELEGANS
  • 2003
VIEW 11 EXCERPTS
HIGHLY INFLUENTIAL

Negative regulation of male development in Caenorhabditis elegans by a protein±protein interaction between TRA-2A and FEM-3

A. Mehra, J. Gaudet, L. Hick, P. E. Kuwabara, A. M. Spence
  • Genes Dev.,
  • 1999
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL