The TNF receptor superfamily: role in immune inflammation and bone formation.

@article{Cheng2003TheTR,
  title={The TNF receptor superfamily: role in immune inflammation and bone formation.},
  author={Xin Cheng and Masa Kinosaki and Ramachandran Murali and M ichael Greene},
  journal={Immunologic research},
  year={2003},
  volume={27 2-3},
  pages={287-94}
}
Tumor necrosis factor (TNF) and TNF receptor (TNFR) family proteins play important roles in many biological processes. Recently, the TNF-family molecule, RANKL (also called TRANCE, ODF, and OPGL), and its receptors, RANK and OPG, were found to be regulators of the development and activation of osteoclasts in bone remodeling. TNFalphaalso activates osteoclasts both by themselves and in synergy with RANKL. We used structure-based design to create peptidomimetics and organic therapeutics that… CONTINUE READING