The TNF ligand superfamily and its relevance for human diseases.

  title={The TNF ligand superfamily and its relevance for human diseases.},
  author={H J Gruss and Steven K. Dower},
  journal={Cytokines and molecular therapy},
  volume={1 2},
The tumor necrosis factor (TNF) receptor superfamily comprises 10 different members of type I integral membrane glycoproteins with characteristic limited sequence homology for the extracellular cysteine-rich repeats. A parallel existing TNF ligand superfamily has been discovered by cloning of ligands for all of the TNF receptor superfamily members. These molecules are type II membrane glycoproteins, with the exception of LT-alpha, which is the only secreted protein of the family. TNF and CD95L… CONTINUE READING
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