The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation.

@article{Ma2013TheTF,
  title={The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation.},
  author={Jianhui Ma and Bo-Ram Bang and Jiawei Lu and So-Young Eun and Motoyuki Otsuka and Michael Croft and Peter Tobias and Jiahuai Han and Osamu Takeuchi and Shizuo Akira and Michael Karin and H. Yagita and Young Jun Kang},
  journal={Science signaling},
  year={2013},
  volume={6 295},
  pages={ra87}
}
Activation of Toll-like receptor (TLR)-dependent signaling leads to the expression of genes encoding proinflammatory factors, such as tumor necrosis factor-α (TNF-α), and this proinflammatory gene expression is sustained for the duration of the inflammatory response. TLR4-mediated inflammation, which occurs in two phases, depends on the TNF family member 4-1BB ligand (4-1BBL) to sustain TNF-α production during late-phase signaling. We showed that Toll-interleukin-1 receptor (TIR) domain… CONTINUE READING
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