The TNF and TNF Receptor Superfamilies Integrating Mammalian Biology

@article{Locksley2001TheTA,
  title={The TNF and TNF Receptor Superfamilies Integrating Mammalian Biology},
  author={Richard M Locksley and Nigel Killeen and Michael J Lenardo},
  journal={Cell},
  year={2001},
  volume={104},
  pages={487-501}
}
The receptors and ligands in this superfamily have unique structural attributes that couple them directly to signaling pathways for cell proliferation, survival, and differentiation. Thus, they have assumed prominent roles in the generation of tissues and transient microen-capabilities are crucial in coordinating the proliferation and protective functions of pathogen-reactive cells. Here, we review the organization of the TNF/TNFR SF and how these proteins have been adapted for pro-Bethesda… CONTINUE READING
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