The TNF-alpha transgenic mouse model of inflammatory arthritis.

  title={The TNF-alpha transgenic mouse model of inflammatory arthritis.},
  author={Ping Li and Edward M Schwarz},
  journal={Springer seminars in immunopathology},
  volume={25 1},
Rheumatoid arthritis is a chronic inflammatory disorder that affects multiple peripheral joints. It is the most common form of inflammatory arthritis and is characterized by synovial hyperplasia, immune cell infiltration, cartilage destruction, and bone erosion. To gain insight into the etiology of the disease, a variety of animal models have been established. Twelve years ago George Kollias' laboratory generated a transgenic (Tg) mouse that over-expresses human TNF-alpha, and develops an… CONTINUE READING

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