The TNF-alpha gene NcoI polymorphism at position -308 of the promoter influences insulin resistance, and increases serum triglycerides after postprandial lipaemia in familiar obesity.

@article{Wybraska2003TheTG,
  title={The TNF-alpha gene NcoI polymorphism at position -308 of the promoter influences insulin resistance, and increases serum triglycerides after postprandial lipaemia in familiar obesity.},
  author={Iwona Wybrańska and Małgorzata Malczewska-Malec and Sylwia Niedbał and Jerzy W. Naskalski and Aldona Dembińska-Ki{\'e}c},
  journal={Clinical chemistry and laboratory medicine},
  year={2003},
  volume={41 4},
  pages={501-10}
}
Tumour necrosis factor alpha (TNF-alpha), acting as a modulator of gene expression in adipocytes, has been linked to the development of insulin resistance and obesity. The aim of this study was to investigate whether the A/G variation at position -308 in the TNF-alpha promoter influences the body weight, insulin resistance, and postprandial lipaemia in Polish Caucasians. One hundred twenty one subjects, 38 men and 83 women, representing 40 obese families, were genotyped by polymerase chain… CONTINUE READING
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