The TNF-Family Cytokine TL1A Promotes Allergic Immunopathology through Group 2 Innate Lymphoid Cells

@inproceedings{Meylan2014TheTC,
  title={The TNF-Family Cytokine TL1A Promotes Allergic Immunopathology through Group 2 Innate Lymphoid Cells},
  author={Françoise Meylan and Eric T Hawley and Luke Barron and Jillian L Barlow and Pallavi Penumetcha and Martin Pelletier and Giuseppe Scium{\`e} and Arianne C Richard and Erika T. Hayes and Julio Gomez-Rodriguez and Xi Chen and William E. Paul and Thomas A. Wynn and Andrew N. J. McKenzie and Richard M Siegel},
  booktitle={Mucosal Immunology},
  year={2014}
}
The tumor necrosis factor (TNF)-family cytokine TL1A (TNFSF15) costimulates T cells and promotes diverse T cell-dependent models of autoimmune disease through its receptor DR3. TL1A polymorphisms also confer susceptibility to inflammatory bowel disease. Here, we find that allergic pathology driven by constitutive TL1A expression depends on interleukin-13 (IL-13), but not on T, NKT, mast cells, or commensal intestinal flora. Group 2 innate lymphoid cells (ILC2) express surface DR3 and produce IL… CONTINUE READING