The TNF-863A allele strongly associates with anticentromere antibody positivity in scleroderma.

@article{Sato2004TheTA,
  title={The TNF-863A allele strongly associates with anticentromere antibody positivity in scleroderma.},
  author={Hiroe Sato and Anna L. Lagan and Christina Alexopoulou and Dimitris A Vassilakis and Tariq Ahmad and Panagiotis Pantelidis and Srihari Veeraraghavan and Elisabetta A Renzoni and Chris P Denton and Carol Black and Athol U Wells and Roland M du Bois and Kenneth I. Welsh},
  journal={Arthritis and rheumatism},
  year={2004},
  volume={50 2},
  pages={558-64}
}
OBJECTIVE Scleroderma is characterized by the presence of 3 predominant, yet almost mutually exclusive, antibodies: anticentromere antibody (ACA), antitopoisomerase antibody, and anti-RNA polymerase antibody. The purpose of this study was to investigate tumor necrosis factor (TNF) polymorphisms in scleroderma, with the specific aim of determining whether TNF polymorphisms would prove to be stronger markers for ACA than class II major histocompatibility complex (MHC). METHODS We studied 214 UK… CONTINUE READING