The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model

@inproceedings{Murai2016TheTC,
  title={The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model},
  author={Kiyohito Murai and Guoqiang Sun and Peng Ye and Erming Tian and Su Cheol Yang and Qi Cui and Guihua Sun and Daniel Trinh and Olivia Sun and Teresa B. Hong and Zhexing Wen and Markus Kalkum and Arthur D. Riggs and Hongjun Song and Guoli Ming and Yan-hong Shi},
  booktitle={Nature communications},
  year={2016}
}
Dysregulated expression of miR-219, a brain-specific microRNA, has been observed in neurodevelopmental disorders, such as schizophrenia (SCZ). However, its role in normal mammalian neural stem cells (NSCs) and in SCZ pathogenesis remains unknown. We show here that the nuclear receptor TLX, an essential regulator of NSC proliferation and self-renewal, inhibits miR-219 processing. miR-219 suppresses mouse NSC proliferation downstream of TLX. Moreover, we demonstrate upregulation of miR-219 and… CONTINUE READING