The TLR9 ligand CpG promotes the acquisition of Plasmodium falciparum-specific memory B cells in malaria-naive individuals.

@article{Crompton2009TheTL,
  title={The TLR9 ligand CpG promotes the acquisition of Plasmodium falciparum-specific memory B cells in malaria-naive individuals.},
  author={Peter D Crompton and Marko Mircetic and Greta E. Weiss and Amy Baughman and Chiung-yu Huang and David J. Topham and John Jay Treanor and Ig{\~n}acio Sanz and F. Eun-Hyung Lee and Anna Durbin and Kazutoyo Miura and David L. Narum and Ruth D. Ellis and Elissa Malkin and Gregory E. D. Mullen and Louis H. Miller and Laura B. Martin and Susan K Pierce},
  journal={Journal of immunology},
  year={2009},
  volume={182 5},
  pages={3318-26}
}
Despite the central role of memory B cells (MBC) in protective immune responses, little is understood about how they are acquired in naive individuals in response to Ag exposure, and how this process is influenced by concurrent activation of the innate immune system's TLR. In this longitudinal study of malaria-naive individuals, we examined the MBC response to two candidate malaria vaccines administered with or without CpG, a TLR9 ligand. We show that the acquisition of MBC is a dynamic process… CONTINUE READING

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