The TIR domain of TIR-NB-LRR resistance proteins is a signaling domain involved in cell death induction.

@article{Swiderski2009TheTD,
  title={The TIR domain of TIR-NB-LRR resistance proteins is a signaling domain involved in cell death induction.},
  author={Michal R. Swiderski and Doris Birker and Jonathan D. G. Jones},
  journal={Molecular plant-microbe interactions : MPMI},
  year={2009},
  volume={22 2},
  pages={157-65}
}
In plants, the TIR (toll interleukin 1 receptor) domain is found almost exclusively in nucleotide-binding (NB) leucine-rich repeat resistance proteins and their truncated homologs, and has been proposed to play a signaling role during resistance responses mediated by TIR containing R proteins. Transient expression in Nicotiana benthamiana leaves of "TIR + 80", the RPS4 truncation without the NB-ARC domain, leads to EDS1-, SGT1-, and HSP90-dependent cell death. Transgenic Arabidopsis plants… CONTINUE READING

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