The TH1/TH2 paradigm in allergy.

  title={The TH1/TH2 paradigm in allergy.},
  author={Enrico Maggi},
  journal={Immunotechnology : an international journal of immunological engineering},
  volume={3 4},
  • Enrico Maggi
  • Published 1998 in
    Immunotechnology : an international journal of…
Recent evidence has been accumulated to suggest that allergen-reactive type 2 helper T cells (Th2) play a triggering role in the activation and/or recruitment of IgE antibody-producing B cells, mast cells and eosinophils, i.e. the cellular triad involved in the allergic inflammation. Interleukin (IL)-4 production by a still unknown cell type (T cell subset, mast cell/basophil?) at the time of antigen presentation to the Th cell is critical for the development of Th2 cells. Other cytokines, such… CONTINUE READING


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