The TGR5 receptor mediates bile acid-induced itch and analgesia.

@article{Alemi2013TheTR,
  title={The TGR5 receptor mediates bile acid-induced itch and analgesia.},
  author={Farzad Alemi and Edwin Kwon and Daniel P Poole and Tinamarie Lieu and Victoria Lyo and Fiore Cattaruzza and Ferda Cevikbas and Martin S Steinhoff and Romina Nassini and Serena Materazzi and Raquel Guerrero-Alba and Eduardo Valdez-Morales and Graeme S Cottrell and Kristina Schoonjans and Pierangelo Geppetti and Stephen J. Vanner and Nigel W Bunnett and Carlos U. Corvera},
  journal={The Journal of clinical investigation},
  year={2013},
  volume={123 4},
  pages={
          1513-30
        }
}
Patients with cholestatic disease exhibit pruritus and analgesia, but the mechanisms underlying these symptoms are unknown. We report that bile acids, which are elevated in the circulation and tissues during cholestasis, cause itch and analgesia by activating the GPCR TGR5. TGR5 was detected in peptidergic neurons of mouse dorsal root ganglia and spinal cord that transmit itch and pain, and in dermal macrophages that contain opioids. Bile acids and a TGR5-selective agonist induced… CONTINUE READING

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