The TGF-beta signaling pathway is essential for Drosophila oogenesis.

  title={The TGF-beta signaling pathway is essential for Drosophila oogenesis.},
  author={Vern Twombly and Ronald K. Blackman and Hao Jin and Jonathan M. Graff and Richard W Padgett and William M. Gelbart},
  volume={122 5},
We examine roles of signaling by secreted ligands of the TGF-beta family during Drosophila oogenesis. One family member, the DPP ligand encoded by the decapentaplegic (dpp) gene, is required for patterning of anterior eggshell structures. This requirement presumably reflects the expression pattern of dpp in an anterior subset of somatic follicle cells: the centripetally migrating and the nurse cell-associated follicle cells. Similar requirements are also revealed by mutations in the saxophone… CONTINUE READING
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