The TGF-β signalling negative regulator PICK1 represses prostate cancer metastasis to bone

Abstract

Backgroud:Constitutive activation of TGF-β signalling is a well-recognised mechanism in bone metastasis of prostate cancer (PCa). Protein Interacting with PRKCA 1 (PICK1) is a critical negative regulator of the TGF-β pathway. However, the clinical significance and biological role of PICK1 in PCa bone metastasis remain obscure.Methods:PICK1 expression is… (More)
DOI: 10.1038/bjc.2017.212

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@article{Dai2017TheTS, title={The TGF-β signalling negative regulator PICK1 represses prostate cancer metastasis to bone}, author={Yuhu Dai and Dong Ren and Qing Yang and Yanmei Cui and Wei Guo and Yingrong Lai and Hong Du and Chuyong Lin and Jun Li and Li-bing Song and Xinsheng Peng}, journal={British Journal of Cancer}, year={2017}, volume={117}, pages={685-694} }