The TGF-β signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer

@article{Kleeff1999TheTS,
  title={The TGF-β signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer},
  author={Joerg Kleeff and Toshiyuki Ishiwata and Hidetoshi Maruyama and Helmut Friess and Patrick Truong and Markus W. B{\"u}chler and Dean Falb and Murray Korc},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={5363-5372}
}
Transforming growth factor-beta (TGF-β) signaling is dependent on the heterodimerization of the type II TGF-β receptor (TβRII) with the type I TGF-β receptor (TβRI). Activated TβRI then mediates TGF-β signals by inducing the phosphorylation of Smad2 and/or Smad3, which separately hetetorodimerize with Smad4 and translocate to the nucleus. Phosphorylation of Smad2/Smad3 by activated TβRI is inhibited by two newly discovered members of the Smad family, Smad6 and Smad7. We now report that Smad7… CONTINUE READING
40 Citations
12 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 40 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 12 references

Ann

  • J. MassagueÂ
  • Rev. Biochem., 67, 753 ± 791.
  • 1998
Highly Influential
6 Excerpts

Mol

  • J Carcamo, FM Weis, +4 authors J. MassagueÂ
  • Cell. Biol., 14, 3810 ± 3821.
  • 1994
Highly Influential
6 Excerpts

Am

  • T Ishiwata, H Friess, MW BuÈ chler, ME Lopez, M. Korc
  • J. Pathol., 153, 213 ± 222.
  • 1998
1 Excerpt

Biochem

  • M Afrakhte, A Moren, +6 authors P. ten Dijke
  • Biophys. Res. Commu., 249, 505 ± 511.
  • 1998
1 Excerpt

Genes Chrom

  • K Venkatasubbarao, MM Ahmed, +6 authors JW. Freeman
  • Cancer, 22, 138 ± 144.
  • 1998
1 Excerpt

Breast Cancer Res

  • J Grondahl Hansen, SG Hilsenbeck, IJ Christensen, GM Clark, CK Osborne, N. BruÈ nner
  • Treat., 43, 153 ± 163.
  • 1997
1 Excerpt

Jpn

  • C Maesawa, G Tamura, +9 authors R. Satodate
  • J. Cancer Res., 88, 340 ± 343.
  • 1997

Oncol

  • M. Reiss
  • Res., 9, 447 ± 457.
  • 1997
1 Excerpt

Proc

  • JN Topper, J Cai, +10 authors D. Falb
  • Natl. Acad. Sci. USA, 94, 9314 ± 9319.
  • 1997

Int

  • RL Baldwin, H Friess, +4 authors M. Korc
  • J. Cancer, 67, 283 ± 288.
  • 1996
9 Excerpts

Similar Papers

Loading similar papers…